Combining scientific investigation with empathy, humour, and artistic curiosity, Go/No-Go is a groundbreaking addition to an urgent dialogue about mental health.

In 2022, during a period of creative and emotional crisis, Marianne Apostolides stumbled upon a scientific article that would profoundly change her understanding of the human mind. Ten months later, she was interviewing the article’s lead author and embarking on a complex and revelatory journey to unravel current approaches to mental health.

Go/No-Go documents Apostolides’s quest to decipher the research underlying new treatments for mental disorders—and to understand how that research is reshaping our fundamental sense of ourselves. She talks with leading neuroscientists, gathering information about their studies, their methods, and the resulting treatments that are in the pipeline. All the while, she reflects on her own experiences, making the science more immediate, understandable, and relevant.

With propulsive writing grounded in hard data, Apostolides poses vital questions that prompt us to look at how contemporary neuroscience is redefining who we are and why we struggle. In Go/No-Go, we come to see the flaws and failures of the current approach to mental health—while also learning how society can change course to better support people on their own journey.